Table 2. Likely Uox−∕− rats screened out from F0 offspring*.
The dead rats were identified based on the uric acid in their kidney above 1,000 g/(g tissue).
| Cage | Offspring (Male/Female) |
aLikely Uox −∕− rats (Male/Female) |
Other rats (Male/Female) |
Note |
|---|---|---|---|---|
| 1 | 9 (4/5) | 7 (2/5), diedb | 2 (2/0) | From third round Uox +∕− rats |
| 2 | 3 (2/1) | 3 (2/1), diedb | 0 | From third Uox +∕− rats |
| 3 | 14 (8/6) | 6 (3/3) | 8 (5/3) | From fourth Uox +∕− rats |
Notes.
a
Male rats with SUA above 40 g/ml or female rats with SUA above 30 g/ml were recognized as likely Uox-/- rats.
b
Likely Uox-/- rats died several days after birth.
*
The number of offspring (F1) was 6 (3/3, male/female), the number of F2 animal was 48 (22/26), the number of F3 animal was 105 [47/(58-1)], the number of F4 animal was 47 [(14-1)/33], the number of F5 animal was 70 (36/34), and the number of F6 animal was 75 (41/34).