Table 3. Genes associated with uric acid transport or metabolism expressed in male rat kidneys (mean ± SD, n = 3).
FPKM, fragment per kilobases of exon model per million mapped reads.
| No | Gene | FPKM | P (a vs b) |
Fold(b/a) | Alias | Note | |
|---|---|---|---|---|---|---|---|
| a wild-type | b Uox−∕− | ||||||
| 1 | Abcg2 | 71.19 ± 10.03 | 79.90 ± 8.91 | 0.324 | 1.12 | BCRP1 | secretion |
| 2 | Abcc4 | 17.17 ± 2.02 | 13.89 ± 1.17 | 0.072 | 0.81 | MRP4 | secretion |
| 3 | Lgals9 | 13.62 ± 2.34 | 7.40 ± 1.77 | 0.021* | 0.54 | UAT | secretion |
| 4 | Slc17a1 | 44.01 ± 4.75 | 54.49 ± 6.00 | 0.077 | 1.24 | NPT1 | secretion |
| 5 | Slc22a6 | 541.93 ± 36.04 | 505.83 ± 51.18 | 0.374 | 0.93 | OA1 | secretion |
| 6 | Slc2a9 | 7.21 ± 0.36 | 7.62 ± 0.37 | 0.237 | 1.06 | GLUT9 | reclamation |
| 7 | Slc2a6 | 1.03 ± 0.057 | 0.88 ± 0.094 | 0.076 | 0.85 | GLUT9 | reclamation |
| 8 | Slc22a13 | 11.67 ± 3.25 | 3.42 ± 0.05 | 0.012* | 0.29 | OAT10 | reclamation |
| 9 | Slc22a8 | 395.78 ± 47.31 | 433.38 ± 31.86 | 0.317 | 1.10 | OAT3 | reclamation |
| 10 | Slc22a12 | 396.99 ± 33.77 | 285.08 ± 43.38 | 0.024* | 0.72 | URAT1 | reclamation |
| 11 | Xdh | 35.45 ± 3.79 | 37.95 ± 3.84 | 0.467 | 1.07 | UOR | synthesis |
| 12 | Uox# | 0.03 ± 0.06 | 0.01 ± 0.01 | 0.507 | 0.25 | UOX | degradation |
| 13 | Ada | 9.59 ± 2.00 | 8.01 ± 1.62 | 0.347 | 0.84 | ADA | synthesis |
Notes.
*
P < 0.05, independent Student’s t-test, two-tailed.
#
The expression of Uox in Uox−∕− rat is invalidated.