Table1.

Association of 42 common tag SNPs in/near IGF-II with maximum BMI and serum IGF-II level in American Indians.

SNP	Position (chr.11, hg19)	Allele 1/2	Allele 1 Frequency	Number of SNPs tagged	Maximum BMI (n=6789) American Indian		Serum IGF-II level (n=911) Full-heritage Pima
					Beta (Loge)	P	Beta	P
rs61867028	2050980	T/C	0.15	singleton	0.004	0.566	13.22	0.1493
rs77530445	2062693	T/C	0.35	singleton	−0.008	0.079	−0.37	0.9571
rs11042391	2063598	A/G	0.13	8	0.006	0.376	−2.04	0.8327
rs7479065	2068717	A/G	0.26	singleton	0.001	0.810	−0.07	0.992
rs148127200	2069207	A/G	0.93	singleton	0.009	0.299	−34.92	0.0054
rs73398037	2070333	T/C	0.58	5	−0.004	0.386	−0.61	0.9275
rs74764171	2072834	T/C	0.17	3	0.006	0.311	2.28	0.7853
rs10734645	2073378	T/C	0.74	2	−0.004	0.440	3.43	0.6431
rs4930030	2087220	T/C	0.19	16	0.006	0.285	−4.72	0.5837
rs74048171	2093603	A/C	0.12	30	0.010	0.137	0.74	0.9424
chr11:2118957	2118957	T/G	0.07	singleton	−0.006	0.494	−1.11	0.9283
rs146587171	2123728	A/G	0.33	4	−0.005	0.294	19.21	0.0056
rs145203788	2127329	T/C	0.22	singleton	0.003	0.528	−6.41	0.3985
rs4341514	2141603	A/G	0.09	56	−0.003	0.689	−34.54	0.0088
rs12276321	2143313	T/G	0.06	3	−0.001	0.965	−31.58	0.0208
rs734351	2156213	A/G	0.86	2	0.002	0.757	26.97	0.0051
rs386580953	2156930	A/G	0.14	3	−0.003	0.675	−0.56	0.9509
rs3213216	2158179	T/C	0.44	singleton	0.006	0.175	−7.39	0.2424
rs149483638	2161530	T/C	0.15	13	0.004	0.458	−0.67	0.9421
rs3741204	2169908	T/C	0.74	6	0.005	0.299	3.55	0.6281
rs10743144	2170773	T/C	0.29	1	−0.003	0.502	13.20	0.0641
rs6357	2188238	T/C	0.10	singleton	0.005	0.495	−20.15	0.0821
rs6356	2190951	T/C	0.62	1	0.000	0.991	−4.71	0.5057
rs10743152	2195981	T/C	0.46	17	0.002	0.684	−1.36	0.8315
rs11042978	2198418	T/G	0.40	19	−0.005	0.257	−1.26	0.8546
rs11564707	2206387	C/G	0.58	9	0.000	0.917	3.91	0.5527
rs61871274	2207877	T/C	0.28	2	−0.001	0.851	12.12	0.091
rs12418303	2209413	A/G	0.32	6	0.007	0.142	−11.78	0.0936
rs7121197	2213258	T/C	0.89	33	−0.003	0.667	11.54	0.2952
rs10840523	2213452	T/C	0.60	2	0.000	0.952	−3.89	0.5755
rs7124729	2218817	T/G	0.20	1	0.006	0.330	−18.60	0.0294
rs11043069	2220652	T/C	0.31	13	−0.002	0.707	14.30	0.0378
rs117940747	2222748	A/C	0.22	singleton	0.004	0.438	−11.94	0.1294
rs7480143	2225023	T/C	0.06	7	−0.012	0.189	−20.32	0.1459
rs140996354	2232137	T/C	0.16	3	0.005	0.356	5.33	0.5442
rs7121039	2232911	C/G	0.58	53	0.000	0.924	−12.32	0.0671
rs11606404	2241215	A/G	0.89	7	0.005	0.459	10.67	0.3322
rs10765826	2241321	A/G	0.54	8	−0.006	0.188	7.77	0.2281
rs6578246	2245345	A/G	0.56	12	0.011	0.017	−12.00	0.0623
rs4506651	2259087	A/G	0.12	10	0.004	0.598	−12.57	0.2705
rs12278109	2268695	T/C	0.05	5	−0.025	0.010	−8.94	0.5552
rs181911080	2269939	A/G	0.06	singleton	0.002	0.792	35.88	0.0062

SNPs were 100kb up- and down-stream from the IGF-II gene (Chr11:2050980–2269939, hg19). For the BMI analysis, BMI was log_e-transformed to approximate a normal distribution, and the betas and P values are adjusted for age, sex, birth year and the first five genetic principal components. For serum IGF-II analyses, beta and P values are adjusted for age, sex, serum storage time, the first five genetic principal components. Results for both traits are derived from a linear mixed model that accounts for genetic relationships among individuals.