Effects of conoidin A on ventricular inflammation one day after intracerebroventricular injection of lysed-RBC. (A) H&E staining showed material from the lysed RBC within the ventricle that was associated with leukocytes. Immunohistohemistry for myeloperoxidase (MPO), Iba-1 and CD68 demonstrated the presence of both neutrophils (MPO positive) and macrophages (Iba-1 and CD68 positive cells). Conoidin A reduced the percentage of MPO (B), Iba-1 (C) and CD68 (D) positive cells associated with this material compared to vehicle treatment. Values are mean ± SD, n=8, #p<0.01 vs. lysed-RBC + vehicle group. Scale bar= 20μm at low magnification, =10μm at high magnification.