5. Additional summary 1: amphotericin B formulations versus azoles.

Early ART compared with deferred ART for PDH in HIV
Patient or population: adults with HIV and progressive disseminated histoplasmosis Settings: endemic areas Intervention: induction therapy with triazoles Comparison: induction therapy with amphotericin B formulations
Outcomes	Narrative summary	Certainty of the evidence (GRADE)	Comments
Treatment success	No RCTs make direct comparisons of amphotericin B and triazoles. Treatment success of triazoles (other than fluconazole) were 83% and 85% in the 2 studies which reported them.	⊕⊝⊝⊝ Very lowa,b	—
ART: antiretroviral therapy; PDH: progressive disseminated histoplasmosis; RCT: randomized controlled trial.

^aDowngraded two levels for serious imprecision. The CIs are wide due to small numbers of participants.
^bDowngraded one level for serious indirectness. No studies report direct comparisons.