Response option |
Criteria |
Low risk of bias (the study is comparable to a well‐performed randomized trial). |
The study is at low risk of bias for all domains. |
Moderate risk of bias (the study appears to provide sound evidence for a non‐randomized study but cannot be considered comparable to a well‐performed randomized trial). |
The study is at low or moderate risk of bias for all domains. |
Serious risk of bias (the study has some important problems). |
The study is at serious risk of bias in ≥ 1 domain, but not at critical risk of bias in any domain. |
Critical risk of bias (the study is too problematic to provide any useful evidence and should not be included in any synthesis). |
The study is at critical risk of bias in ≥ 1 domain. |
No information on which to base a judgement about risk of bias. |
There is no clear indication that the study is at serious or critical risk of bias and there is a lack of information in ≥ 1 key domains of bias. |
Sterne 2016. |