Review	Commentary on methods	Commentary on outcome
Botero Aguirre 2015	Cochrane review, robust methods.	lAmB less nephrotoxic.
Cano‐Torres 2019	No protocol, registration with PROSPERO or quality assessment.	Aimed to provide estimate of frequency and mortality of histoplasmosis in people living with HIV on HAART in Latin America but heterogeneity precluded aggregated estimates.
Hamill 2013	Single author, narrative drug review. No protocol, registration with PROSPERO, or quality assessment. Limited search strategy.	lAmB safer than conventional AmB with at least equivalent efficacy.
Hughes 2010	Details of methodology not provided. No protocol, registration with PROSPERO, or quality assessment reported. Limited search strategy.	Azoles (except FCN) posed greatest risk of interactions with ART. There was limited evidence that risk was lower with echinocandins. Tenofovir should be used with caution with AmB with close monitoring of renal function advised.
Karimzadeh 2013	5 databases searched. Details of screening not provided. Language restriction. No protocol, registration with PROSPERO, or quality assessment reported.	Coadministration of mannitol did not show any clinically significant benefit in preventing AmB‐induced nephrotoxicity. Lipid formulations are clinically effective and safe at preventing AmB‐induced nephrotoxicity.
Keating 2005	Single author drug profile.	Posaconazole was associated with 100% success rate in histoplasmosis.
Moen 2009	Methodology not reported in detail. Databases searched from 1980 to 2009.No protocol, registration with PROSPERO, or quality assessment reported.	For the treatment of confirmed invasive fungal infections, liposomal AmB was more effective than AmB and remained first‐line option for empirical therapy in people with disseminated histoplasmosis.
Pan 2013	3 databases (English and Chinese) searched. Papers independently reviewed by 2 authors. No protocol or quality assessment reported.	300 cases of histoplasmosis were reported in China from 1990 to 2011, of which 257 had PDH. Cases had a prominent geographical distribution, mainly in vicinity of Yangtze river.
Siberry 2013	Guideline for the prevention and treatment of opportunistic infections in HIV‐exposed and HIV‐infected children. Specialists reviewed the literature for new information since publication of the last guidelines (2009).	AmB is preferred for initial treatment of moderately severe‐to‐severe infections.
Slain 2001	Therapeutic review. Included data from in vitro and preclinical studies as well as Phase 2 and 3 clinical trials. 1 database searched.	Intravenous ITRA is less toxic alternative to AmB for people with pulmonary and extrapulmonary histoplasmosis.
AmB: amphotericin B; ART: antiretroviral therapy; FCN: fluconazole; HAART: highly active antiretroviral therapy; ITRA: itraconazole; lAmB: liposomal amphotericin B; PDH: progressive disseminated histoplasmosis.