Study	Commentary
Armstrong 1988	Overview of the treatment of opportunistic infections in people with AIDS. Highlights lack of evidence for maintenance regimens.
Assi 2006	Case series of gastrointestinal histoplasmosis. None of the patients identified had received HAART.
Barlows 1996	Case study of hypothermia following IV AmB.
Benson 2005	Guidelines for treatment of OI in HIV‐infected adults and children; CDC, NIH, and HIVMA.
Bernard 1989	Case series of treatment with FCN. 1 person with histoplasmosis. Urine still positive at day 75. 20 participants. 10 people living with HIV. Did not report HIV status of the person with histoplasmosis.
Bonifaz 2009	Case series of PDH. Authors did not report any use of ART.
BSAC 1992	Treatment recommendations from British Society for Antimicrobial Chemotherapy.
Caplivski 2005	Case series. 4 participants had histoplasmosis and AIDS.
Carme 1993	Case series. 14 participants with Histoplasma duboisii seen in Congo.
Chastain 2017	Review update on epidemiology, diagnosis, and management of OIs in people living with HIV.
Del 1990	Case series; authors do not report outcomes by treatment regimen.
Ferguson‐Paul 2018	Case series of disseminated histoplasmosis in paediatric kidney transplant recipients.
Ferreira 2002	Case series of participants with oral manifestations of histoplasmosis. 8/10 people living with HIV.
Gustafson 1985	Case report in letter to editor of Archives of Internal Medicine detailing failure of ketoconazole as maintenance therapy.
Hage 2011	Antigen clearance study.
Hajjeh 2001	Case‐control study to identify risk factors for histoplasmosis among people living with HIV.
Harrison 1990	Case report of 2 children. Participant 1 had AIDS and was treated successfully with AmB for induction and maintenance. Participant 2 was HIV positive and died 6 months after diagnosis.
Hostetler 1991	Review of use of ITRA in treatment of systemic fungal infections. 8 participants had histoplasmosis and AIDS. Authors did not report outcomes by treatment regimen or detail ART.
Hung 2004	Prospective single arm. 1 or 2 participants with histoplasmosis. No data on management.
Johnson 1989	Clinical review. Comparison of case series of 64 participants with PDH and AIDS with summaries of 61 participants in published literature.
Johnson 1986	Case series. Comparison of case series of 12 cases with summaries of 20 previously reported cases.
Johnson 1988	Case series. 48 participants with PDH and AIDS. Concluded that because of the permanence of immunodeficiency, PDH was resistant to treatment in this population.
Kassamali 2012	Case series, some of whom may have had PDH, but insufficient data reported.
LeMonte 2000	MICs determined to 10 clinical isolates to investigate efficacy of combined treatment with FCN and AmB. Caution against use of FCN+AmB for treatment of histoplasmosis.
Lewin 1995	Case report.
Machado 1991	Case series of 6 people living with HIV with cutaneous‐mucosal involvement of histoplasmosis.
Majluf‐Cruz 1993	Case series of 3 cases with haemophagocytic syndrome associated with histoplasmosis and AIDS.
Marianelli 2014	Case report of IRIS in people living with HIV with histoplasmosis osteomyelitis.
Mashayekhi 2016	Renal transplant recipients with histoplasmosis.
Mazumder 2007	Retrospective case‐control study of people living with HIV with CD4 count < 50 cells/μL and PDH. 26 cases, 42 controls. On multivariate analysis high alkaline phosphatase and weight loss were independent predictors of PDH.
Moazeni 2009	Clinical overview of OIs in people living with HIV and AIDS.
Murphy 2015	Case series of 3 participants highlighting difficulties managing PDH in resource‐limited settings where lAmB and ITRA are not readily available.
Negroni 1990	Case series. Provided information on outcomes by treatment regimen.
Negroni 1992	Case series of 27 patients with AIDS and PDH. Treated with ITRA 200 mg or 400 mg for 6 months. 23/27 patients assessed as responders given ITRA 100 mg. Mean survival 7.8 months.
Neubauer 1992	Case series of 23 patients with AIDS and PDH. 21/23 patients treated with AmB therapy; formulation not specified.
Oliveira 2007	Case series of 21 patients with PDH and AIDS.
Pamnani 2009	Case series of 4 patients with PDH. 2 were people living with HIV.
Restrepo 2007	Case series. 6 patients. 3 were people living with HIV and PDH.
Reyes 2003	Case series. 3 patients with AIDS and cutaneous manifestations of histoplasmosis.
Scharfstein 1997	Cost‐effectiveness modelling for FCN used as prophylaxis for AIDS‐related systemic fungal infections.
Townsend 2015	Case series of histoplasmosis‐induced haemophagocytic syndrome.
Vantilcke 2014	Case series. PDH found to be the most common febrile OI in Western French Guiana.
Wheat 2006	Susceptibility testing on paired isolates from patients with AIDS who failed on treatment with FCN for histoplasmosis.
Wheat 2007	Guidelines for the management of people with histoplasmosis: 2007 update by the Infection Diseases Society of America.