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. 2020 Apr 20;16(4):e1008662. doi: 10.1371/journal.pgen.1008662

Fig 2. eQTL mapping with local ancestry.

Fig 2

(A) The increased number of African ancestry alleles at rs471568 is associated with the decrease of GSTA2 expression. (B) Enrichment of eQTLs unique to LA adjustment compared with eQTLs unique to PC adjustment in Roadmap histone modifications in liver tissue, showing the significant enrichment in active histone markers (e.g. H3K27ac and H3K4me3) and depletion in repressed marker (e.g. H3K9me3). These findings suggest that the LA adjustment when mapping eQTLs in admixed population may identify potential regulatory SNPs with more functional effects.