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. 2020 Apr 24;35(4):986–998. doi: 10.1093/humrep/deaa034

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Data from the HFEA on the use of PGT, by age group, for the years 2014–2016. (A) PGT-A LBRs per year by age. The fresh PET LBR for under 38 s for the years 2014, 2015 and 2016 was 29.9% (32/107), 36.8% (35/95) and 20.0% (5/25), respectively. The fresh PET LBR for 38 and over for the years 2014, 2015 and 2016 was 31.3% (40/128), 21.2% (28/132) and 25.0% (14/56), respectively. The fresh PTC LBR for under 38 s for the years 2014, 2015 and 2016 was 31.1% (32/103), 30.4% (35/115) and 12.5% (5/40), respectively. The fresh PTC LBR over 38 and over for the year 2014, 2015 and 2016 was 17.9% (40/224), 9.8% (28/285) and 15.1% (14/93), respectively. The frozen PET LBR for under 38 s for the years 2014, 2015 and 2016 was 23.3% (7/30), 29.0% (29/100) and 35.9% (47/131). The frozen PET LBR for ages 38 and over for the years 2014, 2015 and 2016 was 22.8% (8/35), 31.4% (32/102), and 38.1% (53/139), respectively. The frozen PTC LBR for ages under 38 for the years 2014, 2015 and 2016 was 28.0% (7/25), 33.3% (29/87) and 39.5% (47/119), respectively, and the frozen PTC LBR for ages 38 and over for the years 2014, 2015 and 2016 was 25.8% (8/31), 30.2% (32/106) and 34.4% (53/154), respectively. Statistical analysis via an ANOVA test showed no evidence for differences between LBR PTC and PET in terms of age groups (P = 0.146 and P = 0.823, respectfully) or frozen cycles (P = 0.555) but there was a significant difference in fresh cycles (P = 0.023). (B) PGT-M/SR LBRs per year by age. The LBR for fresh PET for under 38 s for the years 2014, 2015 and 2016 were 30.1% (49/163), 44.1% (41/93) and 31.4% (21/67), respectively. The LBR for fresh PET for ages 38 and over for the years 2014, 2015 and 2016 were 9.8% (3/32), 16.1% (5/31) and 23.5% (4/17), respectively. The LBR for fresh PTC under 38 for the years 2014, 2015 and 2016 was 23.2% (49/211), 34.5% (41/119) and 20.0% (21/105), respectively. The LBR for fresh PTC ages 38 and over for the years 2014, 2015, and 2016 was 6.5% (3/46), 15.2% (5/33) and 14.8% (4/27), respectively. The LBR for frozen PET for under 38 s for the years 2014, 2015 and 2016 was 32.5% (107/329), 37.2% (182/489) and 27.2% (191/514). The LBR for frozen PET ages 38 and over for the years 2014, 2015 and 2016 was 42.1%, (8/19), 23.2% (22/95), 32.5% (25/77), respectively. The LBR for frozen PTC for ages under 38 for the years 2014, 2015 and 2016 was 35.1% (107/305), 40.1% (182/454), and 38.1% (191/501), respectively. The LBR for frozen PTC for ages 38 and over for the years 2014, 2015 and 2016 was 17.0% (8/47), 27.2% (22/81) and 33.3% (25/75), respectively. ANOVA analysis was carried out and showed the LBR PTC for both fresh and frozen cycles was higher in patients under 38 years than over 38 years (P = 0.002), whereas the LBR PET did not differ by age (P = 0.077). The LBR PTC and PET did not differ for frozen cycles (P = 0.158) but there was a difference between LBR PTC and PET in fresh cycles (P−0.002).