Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 30;48(8):4448–4462. doi: 10.1093/nar/gkaa201

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — A stereoview of a cartoon diagram of the overall structure of dimer-like MsmTOP1-839t in complex with oligonucleotide MTS2-25. The two MsmTOP1-839t monomers (Mono A and Mono B) are colored in green and cyan, respectively. Their bound MTS2-25 oligonucleotides (MTS2-25 A and MTS2-25 B) are colored in orange and salmon, respectively. The 5′-end regions of the two oligonucleotides primarily mediate the dimerization by forming a 12-base-pair duplex DNA containing six non-Watson–Crick base pairings and mismatches. The 3′-end of the oligonucleotide in one MsmTOP1-839t/MTS2-25 complex interacts with the D6-D7 domains of the other MsmTOP1-839t/MTS2-25 complex. As a result, the N-terminal and C-terminal domains of each MsmTOP1-839t are bound to two opposite strands of an underwound DNA duplex.