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The interaction of the C-terminal domains of MsmTOP1 with ssDNA. (A) The interaction of D6 and D7 domains of MsmTOP1 with a ssDNA. The D6 and D7 are colored in cyan and grey respectively. Their key residues involved in DNA bindings are drawn in stick format. (B) A structure-based sequence alignment of the four C-terminal domains of MsmTOP1. It is likely that the missing aromatic residue at the β2_ β3 turn in D5 will significantly reduce the binding of D5 to ssDNA.
