PDR
|
Locally disordered methylation |
Detects DNAm erosion; CpG-wise score; Fast computation |
Simulated heterogeneity not detected; Dependency on read length and CpG density |
Addressing locally disordered DNA methylation in large cancer datasets |
MHL
|
Methylation haplotypes |
CpG-wise score; Robust to technical setup |
Simulated heterogeneity not detected; Slow computation |
Linking genetically detected haplotypes to DNA methylation haplotypes |
Epipoly
|
Variance among the reads |
Simulated heterogeneity detected; Robust to technical setup |
no CpG-wise score; Few regions captured |
Segmentation into highly and lowly variably methylated regions for large bisulfite sequencing datasets |
Entropy
|
Variance among the reads |
Simulated heterogeneity detected; Robust to technical setup |
no CpG-wise score; Few regions captured |
Segmentation into highly and lowly variably methylated regions for large bisulfite sequencing datasets |
FDRP
|
Variance among the reads |
Simulated heterogeneity detected CpG-wise score |
Dependency on coverage, read length and CpG density; Rather slow computation |
Linking CpG-wise methylation values to epigenetic heterogeneity in large bisulfite sequencing datasets |
qFDRP
|
Variance among the reads |
Simulated heterogeneity detected; Robust to technical setup; CpG-wise score |
Rather slow computation |
Linking CpG-wise methylation values to epigenetic heterogeneity in large bisulfite sequencing datasets |