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. 2020 Mar 17;48(8):4382–4395. doi: 10.1093/nar/gkaa164

Figure 4.

Figure 4.

Palmitate conjugation increases ASO affinity for several plasma proteins and lipid complexes. Binding of ASO and Palm-ASO to a set of human plasma proteins: albumin, transferrin (TF), IgG, fibrinogen, α-2-macroglobulin (A2M) and histidine-rich glycoprotein (HRG); and lipid particles: HDL and LDL. (A) FP binding curves for human serum albumin, HDL and HRG. (B) Ratio of Kds ASO/ Palm-ASO. (C) Table of Kds. (D) ASO and Palm-ASO binding profiles in human and mouse plasma by SEC.