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. 2020 Mar 17;48(8):4066–4080. doi: 10.1093/nar/gkaa159

Figure 6.

Figure 6.

Replication timing on the neutrophil PCHi-C network. (A) A portion of the PCHi-C network for neutrophils (2). (B) Correlation between replication timing (RT) at one promoter node with average RT on interacting promoters. (C) A portion of the PCHi-C PP subnetwork extracted from (a) highlighting interactors of the DDX23 and XRCC6BP1 genes, showing a clear separation between early and late RT neighbourhoods. (D) PP interactions of the DDX23 and XRCC6BP1 genes. DDX23 is an early RT gene involved in splicing which interacts with other early RT genes involved in other basic cellular processes (chromatin remodelling, protein modifications etc. see Supplementary Text). XRCC6BP1 (ATP23) is a gene involved in DNA break repair, often amplified in glioblastoma. Its neighbouring promoters include other cancer-related genes with functions in development, cell cycle control and apoptosis (see Supplementary Text andSupplementary Figure S13).