Table 1.

Studies evaluating the prevalence of chronic neuropathic pain (CNP) after burn injury

Author	Publication year	Study design	Sample size	Study diagnosis of CNP	Prevalence of CNP	Study conclusions
Ward et al. [40]	1989	Retrospective	60	Clinical examination	25%	Prevalence was not due to age, %TBSA or mechanism of burn etiology. No associations were found for developing CNP.
Choiniere et al. [35]	1991	Retrospective	104	Contacting patients by phone and inquiring if they had CNP and if it was associated with the burn injury	82%	Prevalence was not due to age, sex or etiology. CNP was associated with burn size and skin grafting.
Margherita et al. [24]	1995	Prospective	17	Clinical examination and EDS	41%	Burn-associated peripheral neuropathy is associated with thermal injury and may be present as early as one week on EDS.
Malenfant et al. [39]	1996	Retrospective	288	Contacting patients to administer questionnaires and assess if they had CNP and it CNP was associated with the burn injury	36.4%	Prevalence was not due to age, sex, burn etiology or length of time elapsed since injury.
Khedr et al. [38]	1997	Prospective	55	Clinical examination and EDS	29%	Prevalence was attributed to 11% of patients having signs and symptoms of peripheral neuropathy and 18% with findings on EDS. CNP was associated with age >20 years, electric burns involving full-thickness skin and a %TBSA more than 20%.
Dauber et al. [37]	2002	Retrospective	358	Mailing patients questionnaires and inquiring if they had any pain	52%	Only 157 questionnaires completed, 23% survey response rate from the 1551 patients mailed questionnaires.
Schneider et al. [34]	2006	Retrospective	72	Clinical examination	40%	The most common associated sensation was a feeling of pins and needles in 46% of patients with pain.
Gabriel et al. [36]	2009	Prospective	370	Clinical examination and EDS	10.2%	Eight patients completed at least one follow-up examination. On follow-up examination there was significant improvement in clinical symptoms and EDS results without intervention. Four of the 8 patients were classified as having neuropathy with an evaluation at 71 days or less.
Brown et al. [7]	2011	Retrospective	492	Mailing patients questionnaires and inquiring if they had pain	18%	Study had a 23% response rate. Patients with CNP recalled significantly more procedures and dressing changes on questionnaires.
Tamam et al. [8]	2013	Retrospective	648	EDS	7.3%	Of the 47 patients with diagnosed peripheral neuropathy from EDS, 15 patients had polyneuropathy and 32 had mononeuropathy. Polyneuropathy was associated with a greater %TBSA, thermal burns, low-voltage electrical burns and upper and lower extremity burns.

%TBSA percent of total body surface area, EDS electro-diagnostic studies