. 2020 Feb 26;82(4):446–451. doi: 10.1292/jvms.19-0595

Table 3. C_max, AUC_inf and 90% confidence interval (CI) of the estimate of β following the oral administration of sildenafil at 1, 2 and 4 mg/kg in dogs with chronic embolic pulmonary hypertension (CEPH).

	C_max (ng/ml)			β	90%CI	AUC_inf (ng·hr/ml)			β	90%CI

	1 mg/kg	2 mg/kg	4 mg/kg			1 mg/kg	2 mg/kg	4 mg/kg
CEPH (n=4)	154.5	352.5	500.7	0.81	0.62–1.00	659.7	1,313.0	2,512.4	0.94	0.65–1.23
Healthy (n=5)^a)	174.9	416.0	1,111.4	1.33	1.17–1.49	791.6	1,593.0	4,319.6	1.23	1.07–1.39

a) For reference, C_max, AUC_inf and 90%CI of the estimate of β in healthy dogs (each n=5) were taken from a previous study [1] in which the same assay as performed in the present study was utilised. C_max, maximum plasma concentration; AUC_inf, area under the curve from time 0 to infinity.

Table 3. Cmax, AUCinf and 90% confidence interval (CI) of the estimate of β following the oral administration of sildenafil at 1, 2 and 4 mg/kg in dogs with chronic embolic pulmonary hypertension (CEPH).

Table 3. C_max, AUC_inf and 90% confidence interval (CI) of the estimate of β following the oral administration of sildenafil at 1, 2 and 4 mg/kg in dogs with chronic embolic pulmonary hypertension (CEPH).