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. Author manuscript; available in PMC: 2020 Dec 19.
Published in final edited form as: J Endocrinol. 2019 Dec 19;244(2):339–352. doi: 10.1530/JOE-19-0273

Figure 1. Schematic design.

Figure 1.

Pregnant sheep were housed in an environmental chamber with elevated temperatures (40 °C for 12 h; 35 °C for 12 h; 35-40% humidity) for 70 days of gestation to produce placental insufficiency and IUGR. Control pregnant sheep were housed in an environmental chamber (21 °C for 24 h; 35-40% humidity) for the same number of days. Six days after fetal vascular catheters were surgically placed, BrdU was administered directly to the fetus by intravenous (IV) bolus injection 24 h and 4 h prior to muscle biopsy.