Table 2.
Fetal weights and physiological measurements.
| Control | IUGR | P-value | |
|---|---|---|---|
| Gestational age (days) | 134.4 ± 0.4 | 134.1 ± 0.3 | 0.5 |
| Male fetus (%) | 50 | 50 | |
| Fetal weight (kg) | 3.3 ± 0.1 | 2.0 ± 0.2 | <0.0005 |
| Biceps femoris (BF; g) | 18.1 ± 0.7 | 9.9 ± 1.0 | <0.0001 |
| Tibialis anterior (TA; g) | 4.0 ± 0.3 | 2.1 ± 0.3 | <0.0005 |
| Flexor digitorum superficialis (FDS; g) | 3.1 ± 0.3 | 1.6 ± 0.2 | <0.0005 |
| Fetal blood gas measurements | |||
| Blood O2 content (mM) | 3.2 ± 0.1 | 1.9 ± 0.3 | <0.01 |
| Blood pH | 7.4 ± 0.0 | 7.3 ± 0.0 | <0.05 |
| Blood PaCO2 (mmHg) | 50.3 ± 0.7 | 51.5 ± 0.7 | 0.3 |
| Blood PaO2 (mmHg) | 20.6 ± 0.7 | 14.6 ± 0.9 | <0.0005 |
| Blood Hgb (mM) | 6.9 ± 0.2 | 6.9 ± 0.3 | 0.9 |
| SaO2 (%) | 48.3 ± 1.8 | 26.6 ± 3.2 | <0.0005 |
| Fetal arterial plasma substrate and hormone concentrations | |||
| Glucose (mM) | 1.0 ± 0.3 | 0.7 ± 0.1 | <0.005 |
| Lactate (mM) | 2.0 ± 0.1 | 2.6 ± 0.2 | 0.07 |
| Insulin (ng/ml) | 0.40 ± 0.09 | 0.14 ± 0.02 | <0.005 |
| IGF-1 (ng/ml) | 108 ± 15 | 46 ± 10 | <0.01 |
| Cortisol (ng/ml) | 20.2 ± 5.3 | 25.3 ± 5.3 | 0.5 |
| Norepinephrine (pg/ml)* | 617 ± 253 | 4313 ± 1960 | <0.005 |
Values are means ± SEM. Control n=8; IUGR n=13. P-values from Student’s t-tests or Mann-Whitney test are shown.
*
Statistical analysis on log-transformed values. Data from this cohort of animals were previously published (Rozance et al., 2018).