Table 2. Sex-specific multivariable adjusted hazard ratios and 95% confidence intervals of non-HDL cholesterol (non-HDL-C) quintiles in relation to the incidence of coronary heart disease and stroke.
| Non-HDL-C quintile |
P for trend |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sex | Q1 | Q2 | Q3 | Q4 | Q5 | Linear | Non-linear | ||
| Men | Range of non-HDL-C, mmol/L (mg/dL) | < 2.87 | 2.87–3.34 | 3.37–3.81 | 3.83–4.38 | ≥ 4.40 | |||
| (111) | (111–129) | (130–147) | (148–169) | (170) | |||||
| Stroke | Cases, n | 182 | 167 | 165 | 138 | 168 | |||
| Person-years | 30,889 | 31,776 | 32,455 | 32,269 | 32,501 | ||||
| Model 1 | 1.00 | 0.92 (0.75–1.14) | 0.90 (0.73–1.11) | 0.79 (0.63–0.99) | 0.99 (0.80–1.22) | > 0.2 | < 0.001 | ||
| Model 2 | 1.00 | 0.90 (0.73–1.11) | 0.87 (0.70–1.08) | 0.76 (0.61–0.96) | 0.92 (0.73–1.15) | > 0.2 | < 0.001 | ||
| CHD | Cases, n | 11 | 23 | 33 | 44 | 67 | |||
| Person-years | 31,724 | 32,536 | 33,237 | 32,744 | 33,009 | ||||
| Model 1 | 1.00 | 2.13 (1.04–4.37) | 3.06 (1.54–6.05) | 4.25 (2.19–8.23) | 6.55 (3.45–12.4) | < 0.001 | N/A | ||
| Model 2 | 1.00 | 1.86 (0.90–3.85) | 2.62 (1.32–5.23) | 3.42 (1.74–6.71) | 4.64 (2.39–8.98) | < 0.001 | N/A | ||
| Women | Range of non-HDLC, mmol/L (mg/dL) | < 3.16 | 3.16–3.63 | 3.65–4.12 | 4.14–4.69 | ≥ 4.71 | |||
| (122) | (122–140) | (141–159) | (160–181) | (182) | |||||
| Stroke | Cases, n | 156 | 175 | 180 | 177 | 197 | |||
| Person-years | 65,792 | 65,478 | 68,115 | 65,347 | 64,538 | ||||
| Model 1 | 1.00 | 0.95 (0.77–1.18) | 0.87 (0.70–1.08) | 0.86 (0.69–1.07) | 0.96 (0.78–1.19) | > 0.2 | N/A | ||
| Model 2 | 1.00 | 0.91 (0.73–1.14) | 0.81 (0.65–1.02) | 0.79 (0.63–0.99) | 0.86 (0.68–1.07) | > 0.2 | N/A | ||
| CHD | Cases, n | 10 | 17 | 25 | 28 | 38 | |||
| Person-years | 66,528 | 66,198 | 68,829 | 66,158 | 65,286 | ||||
| Model 1 | 1.00 | 1.47 (0.67–3.22) | 1.93 (0.93–4.04) | 2.14 (1.04–4.43) | 2.88 (1.43–5.80) | < 0.001 | N/A | ||
| Model 2 | 1.00 | 1.29 (0.59–2.84) | 1.60 (0.76–3.37) | 1.63 (0.78–3.42) | 2.02 (0.97–4.19) | 0.014 | N/A | ||
Model 1 was adjusted for age stratified by community.
Model 2 was further adjusted for smoking status (never, ex-, < 20, or ≥ 20 cigarettes/day in men; or current smoker or not in women), alcohol intake (0, 1–150, 151–300, or ≥ 301 g/week in men; or . 1 day/week alcohol drinker or not in women), sports during leisure time (rarely, 1–2, 3–4 times/week, or almost every day), body mass index, menopause (women only), systolic blood pressure, use of antihypertensive agents, diabetes, HDL-C, and use of antilipemic agents.
Linear trends were tested by using continuous values of non-HDL-C, and non-linear trends were further tested if the fractional polynomial models were fitted at a significance level of p < 0.05. N/A, not applicable.