Table 5. Multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of one standard deviation (SD) increase in non-HDL cholesterol related to the incidence of coronary heart disease (CHD) and stroke subtypes according to the presence/absence of overweight, hypertension, and hypertriglyceridemia in men.
Cardiovascular disease outcomes |
|||||||||
---|---|---|---|---|---|---|---|---|---|
CHD |
Intracerebral hemorrhage |
Large-artery occlusive infarction |
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Cases, n | HR (95% CI)* | P for interaction | Cases, n | HR (95% CI)* | P for interaction | Cases, n | HR (95% CI)* | P for interaction | |
Overweight | |||||||||
No | 111 | 1.71 (1.49–1.97) | 0.91 | 164 | 0.79 (0.66–0.94) | 0.22 | 71 | 1.22 (0.96–1.56) | 0.72 |
Yes | 66 | 1.55 (1.21–1.98) | 67 | 0.96 (0.74–1.24) | 46 | 1.28 (0.94–1.74) | |||
Hypertension | |||||||||
No | 57 | 1.87 (1.56–2.23) | 0.32 | 81 | 0.90 (0.70–1.15) | 0.45 | 47 | 1.34 (1.03–1.75) | 0.34 |
Yes | 120 | 1.55 (1.30–1.85) | 150 | 0.81 (0.68–0.96) | 70 | 1.15 (0.90–1.47) | |||
Hypertriglyceridemia | |||||||||
No | 143 | 1.62 (1.37–1.91) | 0.97 | 202 | 0.85 (0.73–1.00) | 0.49 | 103 | 1.16 (0.94–1.43) | 0.19 |
Yes | 34 | 1.60 (1.22–2.09) | 29 | 0.64 (0.42–0.98) | 14 | 1.83 (1.20–2.79) | |||
Alcohol drinking | |||||||||
No | 91 | 1.95 (1.60–2.36) | 0.008 | 77 | 0.86 (0.68–1.10) | 0.34 | 48 | 1.19 (0.89–1.58) | 0.93 |
Yes | 86 | 1.49 (1.24–1.78) | 154 | 0.83 (0.69–1.00) | 69 | 1.28 (1.00–1.62) |
Adjusted for age, smoking status (never, ex-, < 20, or ≥ 20 cigarettes/day), alcohol intake (0, 1–150, 151–300, or ≥ 301 g/week), sports at leisure time (rarely, 1–2, 3–4 times/week, or almost every day), and body mass index stratified by community. When stratified by alcohol drinking status, it was excluded from the model. HRs are expressed according to SD increase in non-HDL-C.