Table 2. Gastrointestinal and cardiovascular risks of acetaminophen, ibuprofen, naproxen, and COX-2 inhibitors.

Drugs	Gastrointestinal risk	Cardiovascular risk
Acetaminophen	Low	Low
Ibuprofen	Low to moderate	Moderate to high
Naproxen	Moderate to high	Low to moderate
COX-2 inhibitors	Low	High

COX-2: cyclooxygenase-2.