Skip to main content
. 2020 Feb 4;20(2):e15. doi: 10.4110/in.2020.20.e15

Table 1. Strategies to enrich butyrate.

Samples of bacterium/substrate Main findings Ref.
Probiotics
Faecalibacterium prausnitzii F. prausnitzii reduced Clostridium difficile infection in a mouse model. (83)
Bacteroides fragilis In a mouse model, B. fragilis inhibited C. difficile growth with increased butyrate and gut barrier. (84)
Butyricicoccus pullicaecorum Administration of the bacterium decreased colon inflammation through increased production of butyrate in a rat colitis model. (85)
Roseburia hominis Administration of the bacterium increased cecal butyrate content and reduced stress-induced visceral hypersensitivity in rats. (86)
Prebiotics
Inulin Inulin inhibited antibiotics-induced C. difficile infection. (104)
Pectin Fermentation of pectin increased beneficial bacterial growth. (108)
Synbiotics
Bifidobacteria + inulin In co-culture system, the synbiotic effectively inhibited non-probiotic bacterium Bacillus cereus. (110)
F. prausnitzii + potato starch The synbiotic was better than F. prausnitzii alone in inhibiting C. difficile growth. (83)
Bifidobacterium longum + pectin The symbiotic was better than each component alone in inhibiting pathogenic bacteria in the Simulator of the Human Intestinal Microbial Ecosystem. (109)
Fasting mimicking diet (113)
First day intake 50% normal caloric It had anti-inflammatory effect and increased commensal microbiota.
Days 2–4 intake 10% normal caloric