Figure 4. OVA-specific IgE production in serum is reduced in Sesn2^−/− mice. Sesn2^+/+ and Sesn2^−/− mice were immunized with OVA following the protocol described in the Materials and Methods section. Control animals received PBS only. Serum was collected at 7 days after the last immunization, and OVA-specific Ig levels in the indicated serum dilutions were determined by ELISA. Data presented are the means±SEM from three mice from each group (right panel). Sesn2^+/+ mice (n=3), Sesn2^−/− mice (n=3).

NS, not significant.

^*p<0.05, ^***p<0.001.