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. 2019 Dec 11;34(5):1458–1461. doi: 10.1038/s41375-019-0658-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Updated duration on treatment for all patients with MCL (n = 16) according to dose cohort. Dose escalation was permitted at the discretion of the investigator after safety was established. The assigned dose cohort reflects the dose that each patient received for the majority of his or her treatment duration. Asterisk (*) denotes the five ongoing patients. Best overall response for each patient is shown in parentheses. Of the six patients who attained CR, four are ongoing in the study, 1 (#103–106) progressed, and 1 (#202–115) discontinued to undergo allogeneic stem-cell transplantation. Of the five patients who attained PR, one is ongoing in the study and four discontinued due to PD. CR, complete response; MCL, mantle cell lymphoma; NR, no response (did not reach cycle 3); PD, progressive disease; PR, partial response. b Updated PFS curve for patients with MCL. Estimated median PFS was 25.8 months. MCL, mantle cell lymphoma; PFS, progression-free survival.