Skip to main content
. 2019 Feb 23;311(3):141–162. doi: 10.1007/s00403-019-01890-4

Table 3.

Studies examining the association of autoantibodies of IgG class with atopic dermatitis

References Study design and size Diagnostic criteria for AD Methods Prevalence of AR in control subjects Prevalence of AR in patients with AD
Ambrozic et al. [35]

Case–control study

45 patients with AD

26 patients with other atopic conditions (controls)

(All children. Patients with AD ranged from 2 months to 16.8 years, with a mean age of 3.7. Control subjects ranged from 2.1 to 17.8 years, with a mean age of 11.0. Insufficient data to calculate SD)

Moderately Clear

‘Sera selected from the serum banks of the Pediatrics Clinic and Department of Rheumatology (University Medical Centre, Ljubljana)’

ELISA

Specific to Anti-β2GPI

38%

10/26 control patients

42%

19/45 patients with AD

No significant difference

Bergman et al. [31]

Case–control study

37 Patients with Psoriasis

18 patients with AD

56 healthy controls

(All adults. Patients with psoriasis ranged from 20 to 76 years, with a median age of 43.5. Patients with AD ranged from 19 to 69 years, with a median age of 30. Healthy subjects ranged from 27 to 62 years, with a median age of 45.5)

Clear

Hanifin and Rajka

ELISA

Against a variety of autoantigens

Mean Log2Ab Titer of autoantibody (HCs)

TNF-α: 7.61

IFN-α: 7.43

CCL-5: 7.48

CCL-2: 7.84

CCL-3: 7.59

IL-17: 7.41

Mean Log2Ab Titer of autoantibody

TNF-α: 7.94

IFN-α: 7.76

CCL-5: 7.47

CCL-2: 7.41

CCL-3: 8.71 (P = 0.035)

IL-17: 7.59

Du Toit et al. (2006) [16]

Case–control study

33 patients with AEDS

78 patients with Chronic Urticaria

(All children. Patients with AEDS ranged from 1.25 to 19 years, with a mean age of 7.6. Patients with Chronic Urticaria were age matched)

Not clear

Anti–Fcε receptor assays

Specific to IgG FcεR1α autoantibodies

47%

37/78 patients with CU

0%

0/33 patients with AEDS

El-Rachkidy et al. [36]

Case–control study

Patients with psoriasis (number varies based on test)

5 pooled patients with AD

(Age of patients with AD not specified. Psoriasis patients ranged from 22 to 66 years).

Not clear

Immunoblotting and ELISA

Specific to stratum corneum antigens

Psoriasis patients were autoreactive against stratum corneum antigens AD patients were not autoreactive against stratum corneum antigens

Kawamoto et al. [22]

(IgE and IgG)

Case–control study

40 patients with AD

26 control patients (no clinical history of allergic diseases and serum IgE within normal levels)

(Patients with AD ranged from 12 to 44 years, with a mean age of 26.4. Control subjects ranged from 19 to 54 years, with a mean age of 29.2). Insufficient data to calculate SD

Clear

UK Working Party’s Diagnostic Criteria for Atopic Dermatitis

ELISA

Peptide Specific

No significant difference in IgG levels or number of positive samples for 5 peptides

Significant difference in both IgG levels and number of positive samples for SART2161, SART2899, and ART413

Neuber et al. 32]

Case–control study

16 patients with AD

72 healthy control subjects

(All adults. Patients with anti-CD28 autoantibodies had a mean age of 52.3 ± 18.8, patients without anti-CD28 autoantibodies were had a mean age of 58.7 ± 19.9)

Moderately clear

Treated at the Department of Dermatology, University Hospital Eppendorf, Hamburg

ELISA

Specific to Anti-CD28

11.1%

8/72 control patients

87.5%

14/16 AD patients

(P < 0.0001)

Ochs et al. [33]

ANA and IgG

Case–control study

64 patients with eczema

39 control patients

(study also included a range of other atopic conditions)

(Patients with eczema ranged from 4 to 43 years, with a mean age of 24.4. No ages provided for control subjects. Insufficient data to calculate SD)

Clear

Hanifin and Rajka

Indirect immunofluorescence

For ANAs

Western blot

Against anti-DFS70 IgG

ANA not stated

WB-DFS70: 0%

0/39 healthy control subjects

ANA: 41%

26/64 patients

WB-DFS70: 29.6%

19/64 patients

Szakos et al. [34]

IgG and IgM (including ANA)

Case–control study

72 patients with AEDS

22 healthy control patients

(All children. Patients with AEDS ranged from 2 to 17 years, with a mean age of 8 years. Control subjects ranged from 1.5 to 14 years, with a mean age of 8.6 years. Insufficient data to calculate SD)

Not Clear

Indirect immunofluorescence

For ANAs

ELISA

Specific to APLs

9.1%

2/22 healthy control patients had non-allergen-specific IgG and/or IgM antibodies

9.1%

2/22 healthy control patients displayed ANAs

29.3%

21/72 patients had non-allergen-specific IgG and/or IgM antibodies

13.9%

10/72 AD patients displayed ANAs

APL antibodies occurred significantly more often in AD patients