. 2019 Feb 23;311(3):141–162. doi: 10.1007/s00403-019-01890-4

Table 6.

Association of autoantibodies with severity of atopic dermatitis

Marker of autoimmunity	Papers that indicate a link between AD disease severity and autoimmunity	Papers that do not indicate a link between AD disease severity and autoimmunity
IgE autoantibodies	10 Altrichter et al. [18]* Hiragun et al. [20]* Ilves, Virolainen and Harvima [21]* Kinaciyan et al. [48] Kohsaka et al. [49]* Lucae et al. [50] Mittermann et al. [25]* Mothes et al. [26]* Natter et al. [27] Schmid-Grendelmeier et al. [28]*	3 Hide et al. [47] Tanaka et al. [51]^† Zeller et al. [30]^†
ANAs	0	2 Higashi et al. [39]^† Ress et al. [43]^†
Multiple indicators	0	1 Szakos et al., 2004 [34]

Marker of autoimmunity

Papers that indicate a link between AD disease severity and autoimmunity

Papers that do not indicate a link between AD disease severity and autoimmunity

IgE autoantibodies

Altrichter et al. [18]*

Hiragun et al. [20]*

Ilves, Virolainen and Harvima [21]*

Kinaciyan et al. [48]

Kohsaka et al. [49]*

Lucae et al. [50]

Mittermann et al. [25]*

Mothes et al. [26]*

Natter et al. [27]

Schmid-Grendelmeier et al. [28]*

Hide et al. [47]

Tanaka et al. [51]^†

Zeller et al. [30]^†

ANAs

Higashi et al. [39]^†

Ress et al. [43]^†

Multiple indicators

Szakos et al., 2004 [34]

*Differences were statistically significant

†Differences were not statistically significant