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. 2020 Apr 30;11:2104. doi: 10.1038/s41467-020-15903-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Clonogenic Illudin S survival of WT and UVSSA-KO cell lines and the GFP-tagged UVSSA rescue cell lines. Each symbol represents the mean of an independent experiment (n = 3 for all except for GFP-UVSSA^ΔCIR which is n = 2), each of which is based on two technical replicates. Note that the same survival data for UVSSA-KO is also shown in Fig. 4b. b CPD XR-seq repair signal 3 Kb upstream and 5 Kb downstream of the annotated TSS of 16,088 genes in GFP-UVSSA^WT, GFP-UVSSA^ΔCIR, and GFP-UVSSA^ΔTIR. Signal is plotted separately for the transcribed (red) and non-transcribed (black) strands. The data represent the average of two independent experiments for GFP-UVSSA^WT and one single experiment for GFP-UVSSA^ΔCIR and GFP-UVSSA^ΔTIR with a bin size of 53 nt. See also Supplementary Fig. 9 for additional XR-seq data. c Model of how the assembly of CSB, CSA, and UVSSA targets the TFIIH complex to DNA damage-stalled RNAPIIo. Source data are provided as a Source Data file.