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. 2020 Apr 30;10:7340. doi: 10.1038/s41598-020-64226-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overall alteration in the metabolites following myeloid cell-specific VDR deletion: Fold change ratio generated by (A) carbohydrate (B) amino acids (C) lipid and (D) xenobiotics metabolism in VDR^∆lyz mice. The graph represents only those biochemicals showing maximum alterations among known detectable metabolites. Differences are assessed by the Mann–Whitney U test. VDR^∆lyz (N = 10) & VDR^LoxP (N = 16). Significance is established at adjusted 0.05 < P < 0.1.