Figure 2.
Colonization of the respiratory tract by B. pertussis. Naive and vaccinated mice were challenged with B. pertussis (2 × 105 cfu) on day 56 and the number of cfu/ml were subsequently determined on day 1 (d57) and day 6 (d62) post-challenge (p.c.) in (A) lungs, (B) trachea, and (C) nasal lavages (mean with SEM and individual samples). The limit of detection (10 CFU/mL (Log1)) is depicted as horizontal dashed line. Significant differences are indicated by *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 obtained using a t-test after log-transformation of data. NS = not significant.