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. 2020 Apr 30;10:7396. doi: 10.1038/s41598-020-63998-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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T-helper cytokine profiles in splenocytes and lung cells. Concentrations of T-helper 1, 2 and 17-related cytokines were determined in supernatant after 3-day stimulation with OMV of (A) splenocytes and (B) lung cells. Results in pg/mL are corrected for the background level (IMDM complete medium control) and are given as mean±s.d. of 6 mice per group. Significant differences (≥2x alteration compared to naive group) are indicated by *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 obtained using a t-test after log-transformation of data.