Table 1.
Antiviral activity of erucic acid against influenza viruses.
| Virus strain | Erucic acid |
Oseltamivir |
||||
|---|---|---|---|---|---|---|
| TC50 (mM)a | IC50 (mM)b | SIc | TC50 (μM)a | IC50 (μM)b | SIc | |
| A/PR/8/34 (H1N1) | 1.80 ± 0.06 | 0.55 ± 0.08 | 3.30 ± 0.47 | >2500 | 1.22 ± 0.08 | >1000 |
| A/GZ/GIRD07/09 (H1N1) | 1.80 ± 0.06 | 0.50 ± 0.08 | 3.61 ± 0.52 | >2500 | 1.76 ± 0.03 | >1000 |
| A/HK/8/68 (H3N2) | 1.80 ± 0.06 | 1.04 ± 0.11 | 1.74 ± 0.15 | >2500 | 8.31 ± 0.03 | >200 |
| A/HK/Y280/97 (H9N2) | 1.80 ± 0.06 | 0.49 ± 0.09 | 3.65 ± 0.62 | >2500 | 9.93 ± 0.34 | >200 |
| A/Duck/Guangdong/1994 (H7N3) | 1.80 ± 0.06 | 1.24 ± 0.15 | 1.44 ± 0.25 | >2500 | 24.18 ± 1.53 | >100 |
a
TC50 was determined using an MTT assay.
b
IC50 was determined by plaque reduction assay.
c
The selectivity index (SI) was determined as the TC50/IC50 ratio.