Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Result of failure and effects analysis for the PRV virus production process
| Parameters | S | O | D | RPN |
|---|---|---|---|---|
| Medium | 3 | 2 | 3 | 18 |
| Initial cell density | 3 | 2 | 3 | 18 |
| MOI | 3 | 2 | 2 | 12 |
| TOI | 3 | 2 | 1 | 6 |
| DO | 2 | 2 | 1 | 4 |
| Harvest | 2 | 2 | 1 | 4 |
| Temperature | 3 | 1 | 1 | 3 |
| pH | 3 | 1 | 1 | 3 |
| Shear force | 3 | 1 | 1 | 3 |
S, severity of impact, 1, low; 2, moderate; 3, severe, O, probability of occurrence, 1, rare; 2 occasional; 3, frequent D, probability of detection, 1, very good; 2, moderate; 3 bad. Risk priority number (RPN) = S × O × D
