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. 2020 Apr 24;11:385. doi: 10.3389/fgene.2020.00385

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Copyright © 2020 Tan, Tang, Gong, Xie, Lei, Luo, He, Ma and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Technology roadmap. First, the GWAS dataset of colon cancer and rectal cancer were downloaded from GeneATLAS, a large database based on the UK Biobank cohort. Meanwhile, we obtained mRNA expression profiles of CRC from NCBI-GEO. The software FUSION was used to assess the CRC GWAS summary data for tissue-related TWAS analysis. The chemicals related gene sets were then generated by the CTD. Subsequently, chemical-related gene set enrichment analysis (GSEA) was conducted to detect the association between chemicals and CRC. Finally, the Venn diagram showed the significant chemicals associated with colorectal cancer.