| Why carry out this study? |
| Diabetic cardiomyopathy is a cardiac dysfunction in patients with diabetes which may lead to overt heart failure and death. Toll-like receptor (TLR) signaling triggers diabetic cardiomyopathy through various mechanisms, one of which is the upregulation of TLR4 expression |
| The aim of this study was to delineate the role of TLR4 in diabetic cardiomyopathy |
| What was learned from the study? |
| Our study used siRNA to specifically silence TLR4 gene expression in the diabetic mouse heart in vivo and to investigate the role that TLR4 plays in diabetic cardiomyopathy |
| It is likely that silencing of the TLR4 gene through siRNA could prevent the development of diabetic cardiomyopathy |
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