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Candidate methylation site selection using the LASSO Cox regression model. (A) Tenfold cross-validation for tuning parameter selection in the LASSO model using minimum criteria (1-SE). (B) LASSO coefficient profiles of the 69 transcription factors. A coefficient profile plot was produced against the log(lambda) sequence. A vertical line was drawn at the value selected using 10-fold cross-validation where the optimal lambda resulted in 16 non-zero coefficients.
