TABLE 1.

Percentage of transpeptidase sequences with variation in the SXXK, SXN, or K(T/S)G motif of the transpeptidase active sites in PBP1a and PBP2x for S. pneumoniae and S. pyogenes

Motif	No. (%) of variants in:
	S. pneumoniae (n = 2,520)	S. pyogenes (n = 9,667)
PBP1a
STMKa	445 (17.7)	0 (0)
SRN	0 (0)	0 (0)
KTG(T)	0 (0)	0 (0)
PBP2x
STMKa	639 (25.3)	4 (0.04)
SSN	0 (0)	0 (0)
KSG(T)b	0 (3) [0 (0.1)]	0 (0)

^aThe transpeptidase domain sequences as defined in Li et al. (4) were truncated between the S and T of S/TMK.

^bThe two T553K sequences reported to be associated with β-lactam resistance in S. pyogenes in Vannice et al. (2) are not included.