Table 1.

SC compounds identified to have anti-seizure properties in scn1lab mutant zebrafish larvae.

Compound no.	Compound name	Description
10521	JWH 018 N-(5-chloropentyl) analog	JWH 018 is a SC that potently activates the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki = 9.0 and 2.94 nM, respectively). JWH 018 N-(5-chloropentyl) analog differs structurally from JWH 018 by having chlorine added to the five position of the pentyl chain (Aung et al., 2000; Lindigkeit et al., 2009; Uchimaya et al., 2009).
10690	JWH 018 N-(2-methylbutyl) isomer	JWH 018 2-methylbutyl homolog is an analog of JWH 018, a mildly selective agonist of the central cannabinoid receptor (Ki = 8.9 nM) derived from the aminoalkylindole WIN 55,212-2 (Aung et al., 2000).
14550	5-fluoro PB-22 5-hydroxyisoquinoline isomer	5-Fluoro PB-22 is an analog of 5-fluoropentyl JWH-type cannabimimetics. 5-Fluoro PB-22 5-hydroxyisoquinoline isomer differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its five position (Uchimaya et al., 2009).
14766	5-fluoro ADBICA	This compound is a derivative of ADBICA featuring a fluorine atom added to the terminal carbon of the pentyl group (Uchiyama et al., 2012).
9000799	JWH 018 adamantyl analog	JWH 018 adamantyl analog is a mildly selective agonist of the peripheral cannabinoid receptor, where the naphthalene ring is substituted with an adamantyl group (Lu et al., 2005; Sobolevsky et al., 2010).
9001523	AB-FUBINACA 3-fluorobenzyl isomer	AB-FUBINACA is an indazole-based SC that potently binds the central CB1 receptor (Ki = 0.9 nM) (Uchiyama et al., 2012).

SC, synthetic cannabinoid.