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. 2020 Apr 24;11:436. doi: 10.3389/fphar.2020.00436

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Copyright © 2020 Ni, Xu, Xie, Fei, Deng, He, Wang, Liu, Zhu, Xu and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of intrathecal injection of Liquiritin (LQ) on bone cancer pain (BCP)-induced CXCR2 upregulation in the spinal neurons. (A–E) BCP induced a remarkable upregulation of CXCR2 in the ipsilateral spinal dorsal horn. Intrathecal LQ administration inhibited BCP-induced increase in CXCR2 immunoreactivity in the spinal cord. Scale bar 100 μm; mean immunofluorescence intensity (F) and western blot (G) of CXCR2 expressions after different treatments (F_4,15 = 66.22, ^***P < 0.001 vs. sham + Veh group; ^##P < 0.01, ^###P < 0.001, vs. BCP + Veh group; F_4,15 = 72.94, ^***P < 0.001 vs. sham + Veh group; ^###P < 0.001 vs. BCP + Veh group; n = 4, one way ANOVA, 6F, G). (H–J) Immunostaining images demonstrated CXCR2 (green) was predominantly co-localized with NeuN (red) as shown by overlapped staining (the rightmost panel, yellow). Scale bar, 100 μm.