Table 2.

Univariate analysis of MRD and other covariates with RFS, EFS and OS as the outcome.

	RFS			EFS			OS
		95% CI	p-value		95% CI	p-value		95% CI	p-value
Age >10 years (n = 256)
HR	1.10	0.69–1.78	0.68	0.89	0.61–1.3	0.55	0.87	0.56–1.36	0.56
RR	1.14	0.76–1.70	0.53	0.92	0.68–1.24	0.58	0.95	0.65–1.38	0.78
OR	1.19	0.68–2.08	0.53	0.87	0.52–1.44	0.58	0.93	0.54–1.59	0.78
Hyperleukocytosis (n = 256)
HR	2.42	1.5–3.9	0.0002	2.01	1.38–2.95	0.0003	1.96	1.26–3.07	0.0024
RR	1.9	1.25–2.9	0.0027	1.74	1.29–2.34	0.0003	1.60	1.1–2.33	0.013
OR	2.42	1.37–4.26	0.0023	2.63	1.58–4.38	0.0002	1.99	1.16–3.40	0.012
Mediastinal mass (n = 256)
HR	0.79	0.47–1.33	0.40	1.12	0.70–1.64	0.73	1.17	0.72–1.91	0.50
RR	0.82	0.51–1.32	0.41	1.05	0.77–1.44	0.73	1.16	0.78–1.71	0.45
OR	0.76	0.41–1.44	0.40	1.10	0.63–1.90	0.73	1.24	0.70–2.22	0.46
ETP–subtype (n = 256)
HR	0.96	0.48–1.92	0.90	0.80	0.46–1.39	0.46	1.03	0.54–1.96	0.90
RR	0.98	0.54–1.79	0.94	1.22	0.502–1.32	0.41	1.16	0.79–1.72	0.45
OR	0.97	0.43–.220	0.94	1.40	0.34–1.52	0.38	1.24	0.7–2.2	0.45
PIMRD + status (n = 256)
HR	4.71	2.90–7.63	<0.0001	2.01	1.40–3.00	0.0003	1.64	1.05–2.56	0.026
RR	3.93	2.41–6.41	<0.0001	1.80	1.34–2.41	0.0001	1.53	1.06–2.22	0.022
OR	6.47	3.46–12.13	<0.0001	2.82	1.69–4.72	0.0001	1.87	1.09–3.19	0.022
PCMRD + status in PI–MRD+ cases (n = 88)
HR	2.50	1.19–5.25	0.004	2.29	1.17–4.48	0.0048	2.19	1.01–4.71	0.023
RR	1.50	0.96–2.6	0.072	1.50	1.01–2.30	0.046	1.64	0.94–2.86	0.080
OR	2.21	0.91–5.36	0.080	2.39	0.98–5.83	0.05	2.22	0.90–5.45	0.086

CI, confidence interval; EFS, event-free survival; HR, hazard ratio, OR, Odd's ratio; OS, overall survival, RFS, relapse-free survival; RR, relative risk.