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. 2020 Apr 24;10:623. doi: 10.3389/fonc.2020.00623

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Copyright © 2020 Jung, Jang, Kim and Moon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs in the high-grade GEP cohort that are involved in cellular growth and proliferation network, as revealed by IPA (A). Several GO-biologic process terms associated with proliferation were identified in the high-grade GEP cohort (blue) and the low-grade NMIBC cohort (orange) (B). Unsupervised clustering analysis of the DEGs included in the “cell proliferation” (GO: 0008283) GO term in the high-grade GEP cohort (C). Membership search of proliferation-related GO signatures enriched in the high-grade GEP cohort (D). The Ki-67 proliferative index is much higher in CK14-positive tumors than it is in CK14-negative tumors in the prognosis cohort (E).