Table 4.
Functional enrichment in CK14-positive tumors in the high-grade GEP cohort as assessed by Ingenuity Pathway Analysis.
| Category | Function | Activation z-score* | FDR |
|---|---|---|---|
| Cellular Movement | Invasion of tumor cell lines | 1.491 | 0.00251 |
| Cell movement of tumor cell lines | 1.947 | 0.00255 | |
| Invasion of cells | 1.674 | 0.00255 | |
| Migration of tumor cell lines | 2.185 | 0.0058 | |
| Migration of cells | 1.975 | 0.0169 | |
| Cell movement | 1.658 | 0.0182 | |
| Cell death and survival | Necrosis | −1.246 | 0.00218 |
| Apoptosis | −1.159 | 0.00316 | |
| Cell death of tumor cell lines | −1.361 | 0.00393 | |
| Apoptosis of tumor cell lines | −1.658 | 0.0274 |
GEP, gene expression profile; FDR, false discovery rate (Benjamini Hochberg).
*
z-scores indicate activation (>0) or inhibition (<0) of the predicted function based on the fold change of the DEGs (upregulation or downregulation) and its agreement with the functions.