Table 3.
Associations between FAST total score and symptoms reported by phase of depression (acute, post-acute, and remission) in the patient- and HCP-reported cohorts; regression coefficients at the individual symptom level.a
| Patient-reported cohort | HCP-reported cohort | |||||
|---|---|---|---|---|---|---|
| Acute (n = 406) | Post-acute (n = 767) | Remission (n = 773) | Acute (n = 1,005) | Post-acute (n = 1,017) | Remission (n = 1,020) | |
| Mood symptoms | ||||||
| Feeling sad/low | −3.20 | −0.21 | 0.56 | −0.97 | 0.55 | −0.46 |
| Lack of interest in general | 3.94* | 1.64 | 1.80 | 0.41 | 1.34 | 1.67 |
| Unable to take pleasure in things | −0.49 | 0.91 | 0.24 | −1.21 | 1.73 | 1.18 |
| Low self-esteem | −0.05 | 2.04 | 3.20* | 0.16 | 2.44* | 1.44 |
| Lacking in confidence | 1.82 | 1.04 | 1.34 | 0.06 | 0.50 | 3.12* |
| Feelings of guilt or worthlessness | −0.69 | 0.08 | 1.33 | 2.01* | −0.74 | 3.16 |
| Suicidal thoughts | 1.79 | 1.93 | −1.31 | 3.02* | 2.34 | −0.62 |
| Physical symptoms | ||||||
| Lack of energy | 1.99 | 0.60 | 2.68* | 1.06 | 1.76* | 4.01* |
| Reduced activity | 2.40 | 3.45* | −0.24 | 1.49 | 0.99 | 3.52* |
| Difficulty sleeping | −2.30 | 2.25* | 1.42 | 0.07 | −0.06 | −0.74 |
| Feeling tired | −3.03 | −0.79 | 1.29 | −0.83 | −0.22 | 3.10* |
| Waking early in the morning | 0.50 | −1.13 | −0.65 | −0.08 | 0.73 | 4.78* |
| Feeling agitated/restless | −0.11 | −0.01 | 1.05 | 0.39 | −0.11 | 2.60 |
| Weight loss | 0.66 | 2.34 | 0.28 | 0.93 | 2.63 | −2.04 |
| Loss of sex drive | 1.74 | 1.06 | 2.00 | 1.07 | 1.83* | 3.12* |
| Loss of appetite | 1.16 | 0.36 | 3.06 | 0.0002 | 2.37 | 3.54 |
| Depression worst in the morning | 0.59 | 1.12 | −0.83 | 0.54 | 1.51 | −3.09 |
| Cognitive symptoms | ||||||
| Forgetfulness/difficulty remembering | −0.68 | 0.97 | 1.26 | 2.38* | 2.98* | 2.58 |
| Slowness of thinking | 1.60 | 3.10* | 0.86 | 1.57 | 1.24 | 5.31* |
| Slowness in physical movements | 2.55 | 2.14 | −0.98 | 0.75 | 2.28 | 2.08 |
| Difficulty concentrating | 2.83 | 3.01* | 4.62** | 0.91 | 1.39 | 1.15 |
| Difficulty to prioritize/make decisions | −0.58 | 0.81 | 1.61 | 0.66 | −0.38 | 2.15 |
| Difficulty in making plans | 4.47* | 1.06 | 3.85* | 0.59 | 1.36 | 3.12* |
*p < 0.05; **p < 0.0001.
a
Age, sex, country of origin, and level of education were included as covariates in the multivariate regression analysis (data not shown).
Number of patients in the regression model is not identical to the total number of patients included in each cohort due to missing data. FAST, Functioning Assessment Short Test; HCP, healthcare professional.