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. 2020 Apr 24;7:69. doi: 10.3389/fmolb.2020.00069

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Copyright © 2020 Maity and Lyubchenko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AFM force spectroscopy probing of Aβ42 trimer. (A) The schematic for the experimental set up. Three Aβ42 monomers are shown in different colors for clarity. (B) A typical force curve of the force spectroscopy experiment. The blue curve is WLC fitting. (C) The histogram of the rupture forces approximated with a Gaussian (red curve) with the maximum at 75 ± 7 pN. (D) The histogram of contour lengths with the Gaussian fitting. The peak value is 27 ± 6 nm. Number of rupture events used in (B and C) is 137.