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. 2020 Mar 13;4(5):753–768. doi: 10.1002/hep4.1500

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© 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig. 2 — Performance of the multimarker panel and AFP in the diagnosis of HCC. AUROC curve and surveillance ability for the multimarker panel and AFP for all patients with HCC versus high‐risk controls in the training set (A) and validation set (B) (left, AUROC curve; right, bar plot of sensitivity and specificity). The AUROC for the multimarker panel was significantly higher than that of AFP (0.976 vs. 0.804 and 0.898 vs. 0.778 in training and validation sets, respectively). The sensitivities were significantly greater for the multimarker panel than AFP. However, the specificities of the multimarker panel were slightly lower compared with AFP. The AUROC, sensitivity, and specificity of the combination of the multimarker panel with AFP were similar to those of the s panel alone in the training and validation sets. Abbreviation: AUC, area under the curve.