Fig. 3.

Surveillance ability of the multimarker panel in cases with very‐early‐stage HCC. AUROC curves for the multimarker panel and AFP for very‐early‐stage HCC (single size <2 cm) versus controls in the training set (A) and validation set (B) (left, AUROC curve; right, bar plot of sensitivity and specificity). The multimarker panel outperformed AFP with regard to surveillance of very‐early‐stage HCC (0.974 and 0.833 for multimarker panel vs. 0.772 and 0.777 in training and validation sets, respectively). The AUROC of the combination of multimarker panel and AFP was similar to the panel alone in the training and validation sets. The combined model (combination of multimarker panel and AFP) was more sensitive but less specific than the panel alone. Abbreviation: AUC, area under the curve.