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. 2020 Mar 16;4(5):769–782. doi: 10.1002/hep4.1493

Fig. 6.

Fig. 6

Evaluation of HPPS immunogenicity in vivo as evidenced by concentrations of different cytokines 3 hours and 7 days after injection with different concentrations of HPPS and siRNA. Mice were injected in the tail vein with saline (0.3 mL), HPPS (2,000 mg/kg), siRNA HPPS (siRNA 2,000 μg/kg, HPPS 14 mg/kg), or siRNA (2,000 μg/kg). Data show mean ± SEM. *P < 0.05, t test, n = 4. Abbreviations: IL, interleukin; INF, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, saline; RANTES, regulated upon activation, normal T cell expressed, and secreted; TNF, tumor necrosis factor.