Fig. 1.

Effect of BioE‐1115 on oral glucose tolerance test, body weight, plasma glucose insulin, and TGs and mRNA transcripts encoding for lipogenic enzymes in Zucker rats. (A) Age‐matched, 10‐week‐old, female Zucker (fa/fa) rats and their lean littermates (fa/+) were orally dosed once a day for 14 days with 30 or 100 mg/kg BioE‐1115 or vehicle (n = 6‐7 animals/group). Plasma glucose was measured following administration of 2 g/kg glucose by oral gavage. In separate longer term studies, Zucker (fa/fa) rats were dosed orally once daily with vehicle, a commercially available formulation of omega‐3 fatty acids (Lovaza; 110 mg/kg or 352 mg/kg) or BioE‐1115 (3, 10, 30, or 100 mg/kg). (B) Weight was measured throughout. Rats were euthanized and (C) plasma glucose, (D) insulin, and (E) TGs were assessed as were (F) liver mRNA transcripts encoding for SCD1, FAE, ACC, and GPAT. All data represent mean ± SEM. Abbreviation: r, rat.