FIGURE 2.

Formation of CSC and precise targets of CSC pathways. A high dose of radiotherapy has the potential to cure solid tumors via the inactivation of all CSCs. Recurrence can generally be attributed to one or a few remaining CSCs. A combined treatment strategy that precisely targets CSCs or several key molecular signaling pathways in CSC processes to control tumor cell growth would be expected to improve local tumor control. Among of them inhibition of HDAC, Akt/mTOR, HER2, WNT, and HMG CoA reductase inhibition is important to regulate CSCs. While activation of AMPK, manipulation of oxidative stress, and targeting CD44v6 also important of CSC pathways.