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. 2020 Apr 24;8:283. doi: 10.3389/fcell.2020.00283

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Copyright © 2020 Rahman, Saha, Rahman, Uddin, Uddin, Pang, Rhim and Cho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistance of CSCs to chemotherapy via autophagy. Conventional chemotherapy disrupts cell growth; however, CSCs remain unaffected by chemotherapy and sustain autophagy-mediated survival. Sustain cells further recurrence and make tumor heterogeneity along with migration and metastasis. Some cells become death due to therapeutic agents. Secretion of interleukin 6 (IL6) stimulates cancer cells self-renewal and proliferation. Inhibition of autophagy prevents cellular life span in addition to influence apoptotic cell death by chemotherapy. For that reason, targeting autophagy inhibitors in tumors and CSCs might overcome the resistance as well as inhibit tumor growth.